top of page

TMD Outline for Meeting

The Tooth Morphogenesis and Differentiation (TMD) conference was established in 1978 and is held every three to four years at a range of sites across Europe. The meeting brings together researchers and clinicians to discuss and showcase the most recent findings in the field of tooth development and regeneration. Since 1978, participation has increased from 30 to up to 200, attracting leading scientists from the dental and craniofacial fields across the world.


The aim of developmental biology based dental research is to understand the causes underlying dental congenital disorders and malformations and to develop novel diagnostics and therapies. Congenital dental defects are extremely common and include hypodontia (missing teeth), supernumerary tooth formation, taurodontism (root bifurcation defects), enamel and dentine defects, and tooth replacement defects. These can all be associated with syndromes (LADD syndrome, Ectodermal dysplasia, Treacher Collins Syndrome, DiGeorge Syndrome, Cleidocranial dysplasia etc) or be isolated (amelogenesis imperfecta, Msx1, Pax9 mutations etc). Knowledge of how a tooth develops also sheds light on regenerative strategies to encourage tooth repair and in the creation of bioengineered teeth. Tooth development is also an exciting model for how organs develop in the embryo, involving complex epithelial-mesenchymal interactions, the formation of signalling centres, and the use of activator-inhibitor feedback loops to control number and shape. Knowledge gained from tooth development can therefore be applied to many other systems.

An in-depth, interdisciplinary understanding of the developmental biology is an essential foundation for insights into the mechanisms of tooth morphogenesis and the translation of scientific outcomes to clinical management. Such in-depth work probes the cellular events and molecular switches that control tissue patterning and the morphogenetic processes that shape teeth.

Contemporary studies of the tooth development are taking a multidisciplinary approach combining developmental biology with functional genomics, cell biology, biochemistry molecular biology and cellular biology.  As in other fields of developmental biology research, the study of tooth development utilises a range of vertebrate species, to allow study of a variety of shapes and diverse replacement strategies, offering insights into the evolutionary forces and the environmental factors driving the diversity of form and function of these structures.


The 13th Tooth Morphogenesis and Differentiation conference will be held in the UK in September 2019 in the beautiful city of Oxford.  

The conference will be housed in Worcester College, Oxford (founded in 1714), and take advantage of their state of the art conference centre in the college grounds, right in the centre of the city. The program follows the original spirit of TMD meetings, and all participants will be housed at the conference venue to provide maximum opportunity for sharing their common passion for dental and craniofacial research

Program Details: More Info

Program 


Sunday 1st September 2019 


Registration: Worcester College from 3pm 


7-9pm Welcome drinks â€“ Freud Oxford – 119 Walton Street, Oxford OX2 6AH 

​

Monday 2nd September 2019 

​

Registration 8am - 8.45am 

Foyer Lecture theatre 

​

8.45am 

Welcome from the 13th TMD Organising committee 

Paul Sharpe, Abigail Tucker, Martyn Cobourne, Maisa Seppala, Isabelle Miletich 

​

9am - 10.30am  

Morphogenesis and Patterning of the tooth: session 1 

Chair: Paul Sharpe 

​

9am -9.30am 

Ann Huysseune (25 +5mins) 

Pharyngeal tooth development depends on a periderm-like lining of the pharynx. 

​

9.30am -10am 

Jeremy Green (25 +5mins) 

Cell behaviour modules that combine to make the molar: initiation to cap stage  

​

10am -10.30am 

Marcela Buchtova (25 +5mins) 

Enamel knots as conserved signalling centres in reptile tooth morphogenesis 

​

Coffee break (set up posters) 

​

11am – 12.30pm  

Repair: session 1 

Chair: Kristiina Heikinheimo 

​

11am- 11.30am 

Anne Poliard (25 +5mins) 

Priming of DPSC impacts their survival and participation in the repair of critical craniofacial defects  

​

11.30am-12pm 

Hayato Ohshima (25 + 5mins) 

The function of IGFBP3 and IGFBP5 during tooth development and pulpal healing after tooth injury  

​

12pm-12.15pm 

Sanako Makishi (12 + 3mins) 

The effects of recombinant-mouse-osteopontin over dental implant surface on direct osteogenesis in the osseointegration process  

​

12.15-12.30pm 

Pauline Marangoni (12 + 3mins) 

A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage 

​

Lunch Break 

​

1.30pm -3.30pm  

Stem cells in the tooth: session 1 

Chair: Yang Chai 

​

1.30pm-2pm 

Ana Marie Balic (25 + 5mins) 

Functionally distinctive Ptch receptors establish multimodal Hedgehog signalling in the tooth epithelial stem cell niche  

​

2pm-2.30pm 

Ophir Klein (25 + 5mins) 

An alternative splicing network regulates transit-amplifying cell survival to support adult tissue regeneration  

​

2.30pm-3pm 

Han-Sung Jung (25 + 5mins) 

In Vitro Culture and Differentiation of Mouse Dental Epithelial Organoids 

​

3pm-3.15pm 

Annette Merkel (12 + 3mins) 

Endocytosis and Intracellular Trafficking as Gateways for Osteogenic Differentiation of Periodontal Ligament Stem Cells 

​

3.15-3.30pm 

Poster blitz (4 X 3 minutes) 

​

Coffee break 

​

4-6pm Posters 

​

Free time â€“ Croquet and other games (weather permitting) 

​

Tuesday 3rd September 2019 

​

9am - 10.45am  

Disease models: session 1 

Chair: Brad Amendt 

​

9am-9.30am 

Kristiina Heikinheimo (25 + 5mins) 

Molecular pathogenesis of ameloblastoma 

​

9.30am-10am 

Maria Hovorakova (25 + 5mins) 

Impact of disruption of Eda signalling on the early development of incisors and adjacent vestibular epithelium  

​

10am-10.15am 

Tengyang Qiu (12 + 3mins) 

Understanding developmental defects in the vestibular lamina and dental lamina in Ellis-van Creveld syndrome  

​

10.15-10.45am 

Takashi Yamashiro(25 + 5mins) 

Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid 

​

Coffee break 

​

11.15am – 12.30pm  

Tooth, bone and periodontal ligament: session 1 

Chair: Ophir Klein 

​

11.15am-11.45am 

Yang Chai (25 + 5mins) 

Antagonistic interaction between Ezh2 and Arid1a coordinates dental root patterning via Cdkn2a  

​

11.45am-12.15pm 

Eckhard Witten (25 + 5mins) 

The Link between Bone and Tooth Development and Mineralisation 

​

12.15-12.30pm 

Rupali Lav (12 + 3mins) 

Gli1+ stem/progenitor cells are essential sources of Wnts in the developing tooth root  

​

Lunch 

​

1.30-3.30pm  

Tooth replacement strategies and mechanisms 

Chair: Laurent Viriot 

​

1.30pm-2pm 

Joy Richman (25 +5mins) 

Probing the secrets of polyphyodonty in adult geckos 

​

2pm-2.15pm 

Lotta Salomies (12 + 3mins) 

The alternative regenerative strategy of bearded dragon unveils the key processes underlying vertebrate tooth replacement 

​

2.15pm-3.15pm 

Abigail Tucker (25 +5mins) 

Tooth replacement: mechanisms to regulate tooth number 

​

3.15pm-3.30pm  

Kirstin Brink (12 + 3mins) 

Premature tooth extraction does not lead to increased tooth replacement rates in the green iguana 

​

Coffee break 

​

4.30pm Tours Oxford, meet Worcester College Porter’s lodge (entrance) 

​

Wednesday 4th September 2019 

​

9am - 10.30am  

Morphogenesis and patterning of the tooth: session 2 

Chair: Anne Poliard 

​

9am-9.30am 

Sophie Pantalacci (25 +5mins) 

The hidden dynamics of first molar formation in mouse 

​

9.30am-10am 

Marianne Bei (25 +5mins) 

Post-translational modifications regulate transcription factor function during early tooth development  

​

10.am-10.15am 

Alexa Sadier (12 + 3mins) 

Finding new rules for the patterning of post-canine teeth in mammals: insights from Noctilionoid bats  

​

10.15am-10.30am 

Poster blitz (4 X 3 minutes) 

​

Coffee break 

​

11am – 12.45pm  

Evolution  

Chair: Joy Richman 

​

11am-11.30am 

Laurent Viriot (25 +5mins) 

Specialization of jaws and teeth in relation to trophic functions in coral reef fish 

​

11.30am-12am 

Moya Smith (25 +5mins) 

Managing without teeth in the Spookshark, through differentiation and regeneration of hypermineralized dentine aborally  

​

12.am-12.15am 

Aaron Le Blanc ((12 + 3mins) 

The rule and not the exception: palaeontology reveals the ancient history of dental ankylosis  


12.15pm-12.30pm 

Jeremie Viviani (12 + 3mins) 

The same feeding behavior evolved three times independently in parrotfish from different dental arrangements 

​

12.30pm-12.45pm 

Jukka Jernvall (12 + 3 Minutes) 

Does dental variation reflect the level of genotypic variation? 

​

Lunch 

​

1.30-3.30pm  

Disease models: session 2 

Chair: Han-Sung Yung 

​

1.30am-2pm 

Maisa Seppala (25 +5mins) 

Investigation into Wnt signalling as an aetiological factor of odontoma formatio

​

2pm- 2.30pm 

Agnes Bloch-Zupan (25 +5mins) 

SLC10A7 homozygous mutations responsible for variable phenotypes of skeletal dysplasia with Amelogenesis imperfecta  

​

2.30pm-3pm 

Rena D’Souza (25 +5mins) 

Replacement Agonist Therapies that Reverse Secondary Palatal Clefts and Tooth Agenesis Defects in Mice 

​

3pm-3.15pm 

Masato Ota (12 + 3mins) 

Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves  

​

3.15pm-3.30pm 

Raed Said (12 + 3mins) 

Generation and characterization of ameloblast-specific AmelogeninX-iCre/Stromal interaction molecule 1-flox mouse lines for deciphering the mechanisms of calcium-dependent Amelogenesis Imperfecta 

​

Coffee break 

​

4-6pm Posters 

​

Free time 

​

Thursday 5th September 2019 

​

9am - 10.30am  

Repair: session 2 

Chair: Marcela Buchtova 

​

9am-9.30am 

Paul Sharpe (25 +5mins) 

Neuronal regulation of dental pulp stem cell activity 

​

9.30am-10am 

Joo Cheol Park (25 +5mins) 

CPNE7 and its derivative peptide maintain functional activity of mature odontoblasts and promote dentin regeneration  

​

10am-10.30am 

Isabelle Miletich (25 +5mins) 

Salivary gland repair and regeneration 

​

Coffee break 

​

11am – 12.45pm  

Morphogenesis and patterning of the tooth: Session 3 

Chair: Ana Maria Balic 


11am-11.30am 

Georgy Koentges (25 +5mins) 

Crowd-sourced image analysis reveals unexpected dynamics of odontogenic cell lineages  


11.30am-12pm 

Laura Ahtiainen (25 +5mins) 

Initiation Knot Signaling Center Regulates Early Molar Morphogenesis 


12pm-12.30pm 

Martyn Cobourne (25 +5mins) 

Local sonic hedgehog signalling is essential for tongue development 


12.30pm-12.45pm 

Vladimir Soukup (12 + 3 mins) 

The whole axolotl dentition arises from common primordia of odontogenic competence along the ectoderm-endoderm boundary 

​

Lunch 

​

1.30-3.30pm  

Late stages of tooth development: differentiation & mineralisation  

Chair: Sophie Pantalacci 

​

1.30pm-2pm 

Daniel Graf (25 +5mins) 

BMP7 controls the initiation of tooth mineralization  

​

2pm-2.30pm 

Fei Pei (25 +5mins) 

Autophagy regulates odontoblast differentiation and inflammatory defense  

​

2.30pm-2.45pm 

Juan Fons Romero (12 + 3mins) 

The impact of endothelial cells on odontoblast differentiation  

​

2.45pm-3.15pm 

Petros Papagerakis (25 +5mins) 

The Circadian Clock Regulates Amelogenesis in vivo 


3.15pm-3.45pm 

Zhi Chen (25 +5mins) 

Landscape of open chromatin regions during the terminal differentiation of mouse odontoblasts 

​

Coffee break 

​

4-6pm Posters (take down posters by 7pm) 

​

7pm Gala meal Hall 

​

Friday 6th September 2019 

​

9am - 10.30am  

Tooth, bone and periodontal ligament: session 2 

Chair: Maisa Seppala 

​

9am-9.30am 

Tom Diekwisch (25 +5mins) 

The WNT-inhibitor SFRP1 is a quintessential molecule responsible for the non-mineralized state of the periodontium 

​

9.30am-10am 

Ralf Radlanski (25 +5mins) 

Human prenatal craniofacial development as revealed in tungsten-carbide-contrasted Micro-CT, with special reference to peridental structures  

​

10am-10.30am 

Discussions for next meeting 

​

Coffee break 

​

11am – 12pm Session 2 

Stem cells in the tooth: session 2 

Chair: Ann Huysseune 

​

11am-11.30am 

Jan Krivanek (25 +5mins) 

Dental cell type atlas reveals new stem and differentiated cell types in mouse and human teeth  

​

11.30am-12pm 

Brad Amendt (25 +5mins) 

miR-200 Regulates Differentiation and Compartmentalization of the Dental Stem Cell Niche 

​

Closing remarks 

Paul Sharpe, Abigail Tucker, Martyn Cobourne, Maisa Seppala, Isabelle Miletich  

​

​

End of conference 

​

Program Details: More Info
bottom of page