TMD Outline for Meeting
The Tooth Morphogenesis and Differentiation (TMD) conference was established in 1978 and is held every three to four years at a range of sites across Europe. The meeting brings together researchers and clinicians to discuss and showcase the most recent findings in the field of tooth development and regeneration. Since 1978, participation has increased from 30 to up to 200, attracting leading scientists from the dental and craniofacial fields across the world.
The aim of developmental biology based dental research is to understand the causes underlying dental congenital disorders and malformations and to develop novel diagnostics and therapies. Congenital dental defects are extremely common and include hypodontia (missing teeth), supernumerary tooth formation, taurodontism (root bifurcation defects), enamel and dentine defects, and tooth replacement defects. These can all be associated with syndromes (LADD syndrome, Ectodermal dysplasia, Treacher Collins Syndrome, DiGeorge Syndrome, Cleidocranial dysplasia etc) or be isolated (amelogenesis imperfecta, Msx1, Pax9 mutations etc). Knowledge of how a tooth develops also sheds light on regenerative strategies to encourage tooth repair and in the creation of bioengineered teeth. Tooth development is also an exciting model for how organs develop in the embryo, involving complex epithelial-mesenchymal interactions, the formation of signalling centres, and the use of activator-inhibitor feedback loops to control number and shape. Knowledge gained from tooth development can therefore be applied to many other systems.
An in-depth, interdisciplinary understanding of the developmental biology is an essential foundation for insights into the mechanisms of tooth morphogenesis and the translation of scientific outcomes to clinical management. Such in-depth work probes the cellular events and molecular switches that control tissue patterning and the morphogenetic processes that shape teeth.
Contemporary studies of the tooth development are taking a multidisciplinary approach combining developmental biology with functional genomics, cell biology, biochemistry molecular biology and cellular biology. As in other fields of developmental biology research, the study of tooth development utilises a range of vertebrate species, to allow study of a variety of shapes and diverse replacement strategies, offering insights into the evolutionary forces and the environmental factors driving the diversity of form and function of these structures.
The 13th Tooth Morphogenesis and Differentiation conference will be held in the UK in September 2019 in the beautiful city of Oxford.
The conference will be housed in Worcester College, Oxford (founded in 1714), and take advantage of their state of the art conference centre in the college grounds, right in the centre of the city. The program follows the original spirit of TMD meetings, and all participants will be housed at the conference venue to provide maximum opportunity for sharing their common passion for dental and craniofacial research
Program
Sunday 1st September 2019
Registration: Worcester College from 3pm
7-9pm Welcome drinks – Freud Oxford – 119 Walton Street, Oxford OX2 6AH
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Monday 2nd September 2019
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Registration 8am - 8.45am
Foyer Lecture theatre
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8.45am
Welcome from the 13th TMD Organising committee
Paul Sharpe, Abigail Tucker, Martyn Cobourne, Maisa Seppala, Isabelle Miletich
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9am - 10.30am
Morphogenesis and Patterning of the tooth: session 1
Chair: Paul Sharpe
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9am -9.30am
Ann Huysseune (25 +5mins)
Pharyngeal tooth development depends on a periderm-like lining of the pharynx.
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9.30am -10am
Jeremy Green (25 +5mins)
Cell behaviour modules that combine to make the molar: initiation to cap stage
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10am -10.30am
Marcela Buchtova (25 +5mins)
Enamel knots as conserved signalling centres in reptile tooth morphogenesis
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Coffee break (set up posters)
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11am – 12.30pm
Repair: session 1
Chair: Kristiina Heikinheimo
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11am- 11.30am
Anne Poliard (25 +5mins)
Priming of DPSC impacts their survival and participation in the repair of critical craniofacial defects
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11.30am-12pm
Hayato Ohshima (25 + 5mins)
The function of IGFBP3 and IGFBP5 during tooth development and pulpal healing after tooth injury
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12pm-12.15pm
Sanako Makishi (12 + 3mins)
The effects of recombinant-mouse-osteopontin over dental implant surface on direct osteogenesis in the osseointegration process
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12.15-12.30pm
Pauline Marangoni (12 + 3mins)
A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage
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Lunch Break
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1.30pm -3.30pm
Stem cells in the tooth: session 1
Chair: Yang Chai
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1.30pm-2pm
Ana Marie Balic (25 + 5mins)
Functionally distinctive Ptch receptors establish multimodal Hedgehog signalling in the tooth epithelial stem cell niche
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2pm-2.30pm
Ophir Klein (25 + 5mins)
An alternative splicing network regulates transit-amplifying cell survival to support adult tissue regeneration
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2.30pm-3pm
Han-Sung Jung (25 + 5mins)
In Vitro Culture and Differentiation of Mouse Dental Epithelial Organoids
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3pm-3.15pm
Annette Merkel (12 + 3mins)
Endocytosis and Intracellular Trafficking as Gateways for Osteogenic Differentiation of Periodontal Ligament Stem Cells
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3.15-3.30pm
Poster blitz (4 X 3 minutes)
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Coffee break
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4-6pm Posters
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Free time – Croquet and other games (weather permitting)
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Tuesday 3rd September 2019
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9am - 10.45am
Disease models: session 1
Chair: Brad Amendt
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9am-9.30am
Kristiina Heikinheimo (25 + 5mins)
Molecular pathogenesis of ameloblastoma
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9.30am-10am
Maria Hovorakova (25 + 5mins)
Impact of disruption of Eda signalling on the early development of incisors and adjacent vestibular epithelium
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10am-10.15am
Tengyang Qiu (12 + 3mins)
Understanding developmental defects in the vestibular lamina and dental lamina in Ellis-van Creveld syndrome
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10.15-10.45am
Takashi Yamashiro(25 + 5mins)
Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid
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Coffee break
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11.15am – 12.30pm
Tooth, bone and periodontal ligament: session 1
Chair: Ophir Klein
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11.15am-11.45am
Yang Chai (25 + 5mins)
Antagonistic interaction between Ezh2 and Arid1a coordinates dental root patterning via Cdkn2a
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11.45am-12.15pm
Eckhard Witten (25 + 5mins)
The Link between Bone and Tooth Development and Mineralisation
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12.15-12.30pm
Rupali Lav (12 + 3mins)
Gli1+ stem/progenitor cells are essential sources of Wnts in the developing tooth root
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Lunch
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1.30-3.30pm
Tooth replacement strategies and mechanisms
Chair: Laurent Viriot
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1.30pm-2pm
Joy Richman (25 +5mins)
Probing the secrets of polyphyodonty in adult geckos
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2pm-2.15pm
Lotta Salomies (12 + 3mins)
The alternative regenerative strategy of bearded dragon unveils the key processes underlying vertebrate tooth replacement
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2.15pm-3.15pm
Abigail Tucker (25 +5mins)
Tooth replacement: mechanisms to regulate tooth number
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3.15pm-3.30pm
Kirstin Brink (12 + 3mins)
Premature tooth extraction does not lead to increased tooth replacement rates in the green iguana
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Coffee break
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4.30pm Tours Oxford, meet Worcester College Porter’s lodge (entrance)
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Wednesday 4th September 2019
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9am - 10.30am
Morphogenesis and patterning of the tooth: session 2
Chair: Anne Poliard
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9am-9.30am
Sophie Pantalacci (25 +5mins)
The hidden dynamics of first molar formation in mouse
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9.30am-10am
Marianne Bei (25 +5mins)
Post-translational modifications regulate transcription factor function during early tooth development
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10.am-10.15am
Alexa Sadier (12 + 3mins)
Finding new rules for the patterning of post-canine teeth in mammals: insights from Noctilionoid bats
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10.15am-10.30am
Poster blitz (4 X 3 minutes)
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Coffee break
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11am – 12.45pm
Evolution
Chair: Joy Richman
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11am-11.30am
Laurent Viriot (25 +5mins)
Specialization of jaws and teeth in relation to trophic functions in coral reef fish
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11.30am-12am
Moya Smith (25 +5mins)
Managing without teeth in the Spookshark, through differentiation and regeneration of hypermineralized dentine aborally
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12.am-12.15am
Aaron Le Blanc ((12 + 3mins)
The rule and not the exception: palaeontology reveals the ancient history of dental ankylosis
12.15pm-12.30pm
Jeremie Viviani (12 + 3mins)
The same feeding behavior evolved three times independently in parrotfish from different dental arrangements
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12.30pm-12.45pm
Jukka Jernvall (12 + 3 Minutes)
Does dental variation reflect the level of genotypic variation?
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Lunch
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1.30-3.30pm
Disease models: session 2
Chair: Han-Sung Yung
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1.30am-2pm
Maisa Seppala (25 +5mins)
Investigation into Wnt signalling as an aetiological factor of odontoma formatio
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2pm- 2.30pm
Agnes Bloch-Zupan (25 +5mins)
SLC10A7 homozygous mutations responsible for variable phenotypes of skeletal dysplasia with Amelogenesis imperfecta
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2.30pm-3pm
Rena D’Souza (25 +5mins)
Replacement Agonist Therapies that Reverse Secondary Palatal Clefts and Tooth Agenesis Defects in Mice
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3pm-3.15pm
Masato Ota (12 + 3mins)
Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves
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3.15pm-3.30pm
Raed Said (12 + 3mins)
Generation and characterization of ameloblast-specific AmelogeninX-iCre/Stromal interaction molecule 1-flox mouse lines for deciphering the mechanisms of calcium-dependent Amelogenesis Imperfecta
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Coffee break
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4-6pm Posters
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Free time
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Thursday 5th September 2019
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9am - 10.30am
Repair: session 2
Chair: Marcela Buchtova
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9am-9.30am
Paul Sharpe (25 +5mins)
Neuronal regulation of dental pulp stem cell activity
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9.30am-10am
Joo Cheol Park (25 +5mins)
CPNE7 and its derivative peptide maintain functional activity of mature odontoblasts and promote dentin regeneration
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10am-10.30am
Isabelle Miletich (25 +5mins)
Salivary gland repair and regeneration
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Coffee break
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11am – 12.45pm
Morphogenesis and patterning of the tooth: Session 3
Chair: Ana Maria Balic
11am-11.30am
Georgy Koentges (25 +5mins)
Crowd-sourced image analysis reveals unexpected dynamics of odontogenic cell lineages
11.30am-12pm
Laura Ahtiainen (25 +5mins)
Initiation Knot Signaling Center Regulates Early Molar Morphogenesis
12pm-12.30pm
Martyn Cobourne (25 +5mins)
Local sonic hedgehog signalling is essential for tongue development
12.30pm-12.45pm
Vladimir Soukup (12 + 3 mins)
The whole axolotl dentition arises from common primordia of odontogenic competence along the ectoderm-endoderm boundary
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Lunch
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1.30-3.30pm
Late stages of tooth development: differentiation & mineralisation
Chair: Sophie Pantalacci
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1.30pm-2pm
Daniel Graf (25 +5mins)
BMP7 controls the initiation of tooth mineralization
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2pm-2.30pm
Fei Pei (25 +5mins)
Autophagy regulates odontoblast differentiation and inflammatory defense
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2.30pm-2.45pm
Juan Fons Romero (12 + 3mins)
The impact of endothelial cells on odontoblast differentiation
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2.45pm-3.15pm
Petros Papagerakis (25 +5mins)
The Circadian Clock Regulates Amelogenesis in vivo
3.15pm-3.45pm
Zhi Chen (25 +5mins)
Landscape of open chromatin regions during the terminal differentiation of mouse odontoblasts
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Coffee break
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4-6pm Posters (take down posters by 7pm)
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7pm Gala meal Hall
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Friday 6th September 2019
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9am - 10.30am
Tooth, bone and periodontal ligament: session 2
Chair: Maisa Seppala
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9am-9.30am
Tom Diekwisch (25 +5mins)
The WNT-inhibitor SFRP1 is a quintessential molecule responsible for the non-mineralized state of the periodontium
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9.30am-10am
Ralf Radlanski (25 +5mins)
Human prenatal craniofacial development as revealed in tungsten-carbide-contrasted Micro-CT, with special reference to peridental structures
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10am-10.30am
Discussions for next meeting
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Coffee break
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11am – 12pm Session 2
Stem cells in the tooth: session 2
Chair: Ann Huysseune
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11am-11.30am
Jan Krivanek (25 +5mins)
Dental cell type atlas reveals new stem and differentiated cell types in mouse and human teeth
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11.30am-12pm
Brad Amendt (25 +5mins)
miR-200 Regulates Differentiation and Compartmentalization of the Dental Stem Cell Niche
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Closing remarks
Paul Sharpe, Abigail Tucker, Martyn Cobourne, Maisa Seppala, Isabelle Miletich
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End of conference
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